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25-Hydroxyvitamin D and pre-clinical alterations in inflammatory and hemostatic markers: a cross sectional analysis in the 1958 British Birth Cohort

Hypponen, E; Berry, D; Cortina-Borja, M; Power, C; (2010) 25-Hydroxyvitamin D and pre-clinical alterations in inflammatory and hemostatic markers: a cross sectional analysis in the 1958 British Birth Cohort. PLoS One. , 5 (5) , Article e10801. 10.1371/journal.pone.0010801. Green open access

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BACKGROUND: Vitamin D deficiency has been suggested as a cardiovascular risk factor, but little is known about underlying mechanisms or associations with inflammatory or hemostatic markers. Our aim was to investigate the association between 25-hydroxyvitamin D [25(OH)D, a measure for vitamin D status] concentrations with pre-clinical variations in markers of inflammation and hemostasis. METHODOLOGY/PRINCIPAL FINDINGS: Serum concentrations of 25(OH)D, C-reactive protein (CRP), fibrinogen, D-dimer, tissue plasminogen activator (tPA) antigen, and von Willebrand factor (vWF) were measured in a large population based study of British whites (aged 45 y). Participants for the current investigation were restricted to individuals free of drug treated cardiovascular disease (n = 6538). Adjusted for sex and month, 25(OH)D was inversely associated with all outcomes (p < or =0.015 for all), but associations with CRP, fibrinogen, and vWF were explained by adiposity. Association with tPA persisted after full adjustment (body mass index, waist circumference, physical activity, TV watching, smoking, alcohol consumption, social class, sex, and month), and average concentrations were 18.44% (95% CI 8.13, 28.75) lower for 25(OH)D > or =75 nmol/l compared to < 25 nmol/l. D-dimer concentrations were lower for participants with 25(OH)D 50-90 nmol/l compared to others (quadratic term p = 0.01). We also examined seasonal variation in hemostatic and inflammatory markers, and evaluated 25(OH)D contribution to the observed patterns using mediation models. TPA concentrations varied by season (p = 0.02), and much of this pattern was related to fluctuations in 25(OH)D concentrations (p < or =0.001). Some evidence of a seasonal variation was observed also for fibrinogen, D-dimer and vWF (p < 0.05 for all), with 25(OH)D mediating some of the pattern for fibrinogen and D-dimer, but not vWF. CONCLUSIONS: Current vitamin D status was associated with tPA concentrations, and to a lesser degree with fibrinogen and D-dimer, suggesting that vitamin D status/intake may be important for maintaining antithrombotic homeostasis

Type: Article
Title: 25-Hydroxyvitamin D and pre-clinical alterations in inflammatory and hemostatic markers: a cross sectional analysis in the 1958 British Birth Cohort
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0010801
Publisher version: http://dx.doi.org/10.1371/journal.pone.0010801
Language: English
Additional information: © 2010 Hyppönen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: This study was supported by the British Heart Foundation (PG/09/023). Data collection at age 44–46 years and statistical analyses were funded by the UK Medical Research Council (MRC grants G0601653, G0000934), and 25(OH)D assays by the BUPA Foundation. E.H. is a Department of Health (UK) Public Health Career Scientist. This work was undertaken at the Centre for Paediatric Epidemiology and Biostatistics which benefits from funding support from the MRC in its capacity as the MRC Centre of Epidemiology for Child Health. Research at the University College London Institute of Child Health and Great Ormond Street Hospital for Children NHS Trust benefits from R&D funding received from the NHS Executive. The funders had no role in study design, data collection and analyses, decision to publish, or preparation of the manuscript.
Keywords: Adiposity, Aged, analogs & derivatives, analysis, association, Biological Markers, BIOSTATISTICS, blood, Body Mass Index, BRITISH, C-Reactive Protein, CARDIOVASCULAR-DISEASE, Child, cohort, Cohort Studies, Cross-Sectional Studies, deficiency, Disease, epidemiology, Female, Fibrinogen, Great Britain, HEALTH, Hemostasis, Homeostasis, Humans, INDEX, Inflammation, London, Male, mediation, metabolism, Middle Aged, MODELS, Parturition, physical activity, physiology, Population, Research, Risk, Seasons, sex, Smoking, Social Class, Tissue Plasminogen Activator, Vitamin D, Vitamin D Deficiency, von Willebrand Factor, Waist Circumference
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/1319341
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