Jelzow, A;
Tachtsidis, I;
Kirilina, E;
Niessing, M;
Bruhl, R;
Wabnitz, H;
Heine, A;
... Macdonald, R; + view all
(2011)
Simultaneous measurement of time-domain fNIRS and physiological signals during a cognitive task.
In: Hielscher, AH and Taroni, P, (eds.)
DIFFUSE OPTICAL IMAGING III.
SPIE-INT SOC OPTICAL ENGINEERING: Washington, US.
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Abstract
Functional near-infrared spectroscopy (fNIRS) is a commonly used technique to measure the cerebral vascular response related to brain activation. It is known that systemic physiological processes, either independent or correlated with the stimulation task, can influence the optical signal making its interpretation challenging. The aim of the present work is to investigate the impact of task-evoked changes in the systemic physiology on fNIRS measurements for a cognitive paradigm. For this purpose we carried out simultaneous measurements of time-domain fNIRS on the forehead and systemic physiological signals, i.e. mean blood pressure, heart rate, respiration, galvanic skin response, scalp blood flow (flux) and red blood cell (RBC) concentration changes. We performed measurements on 15 healthy volunteers during a semantic continuous performance task (CPT). The optical data was analyzed in terms of depth-selective moments of distributions of times of flight of photons through the tissue. In addition, cerebral activation was localized by a subsequent fMRI experiment on the same subject population using the same task. We observed strong non-cerebral task-evoked changes in concentration changes of oxygenated hemoglobin in the forehead. We investigated the temporal behavior and mutual correlations between hemoglobin changes and the systemic processes. Mean blood pressure (BP), galvanic skin response (GSR) and heart rate exhibited significant changes during the activation period, whereby BP and GSR showed the highest correlation with optical measurements.
| Type: | Proceedings paper |
|---|---|
| Title: | Simultaneous measurement of time-domain fNIRS and physiological signals during a cognitive task |
| Event: | Conference on Diffuse Optical Imaging III |
| Location: | Munich, GERMANY |
| Dates: | 2011-05-22 - 2011-05-24 |
| ISBN-13: | 978-0-81948-685-1 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1117/12.889484 |
| Publisher version: | http://dx.doi.org/10.1117/12.889484 |
| Language: | English |
| Additional information: | © 2011 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. |
| Keywords: | time-domain NIRS, functional brain activation, BA10, physiological signals, systemic effects, NEAR-INFRARED SPECTROSCOPY, TISSUE, FLIGHT |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1319025 |
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