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Brain-Derived Neurotrophic Factor in Patients with Huntington's Disease

Zuccato, C; Marullo, M; Vitali, B; Tarditi, A; Mariotti, C; Valenza, M; Lahiri, N; ... Cattaneo, E; + view all (2011) Brain-Derived Neurotrophic Factor in Patients with Huntington's Disease. PLOS ONE , 6 (8) , Article e22966. 10.1371/journal.pone.0022966. Green open access

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Abstract

Reduced Brain-Derived Neurotrophic Factor (BDNF) levels have been described in a number of patho-physiological conditions, most notably, in Huntington's disease (HD), a progressive neurodegenerative disorder. Since BDNF is also produced in blood, we have undertaken the measurement of its peripheral levels in the attempt to identify a possible link with HD prognosis and/or its progression. Here we evaluated BDNF level in 398 blood samples including 138 controls, 56 preHD, and 204 HD subjects. We found that BDNF protein levels were not reliably different between groups, whether measured in plasma (52 controls, 26 preHD, 105 HD) or serum (39 controls, 5 preHD, 29 HD). Our experience, and a reanalysis of the literature highlighted that intra-group variability and methodological aspects affect this measurement, especially in serum. We also assessed BDNF mRNA levels in blood samples from 47 controls, 25 preHD, and 70 HD subjects, and found no differences among the groups. We concluded that levels of BDNF in human blood were not informative (mRNA levels or plasma protein level) nor reliable (serum protein levels) as HD biomarkers. We also wish to warn the scientific community in interpreting the significance of changes measured in BDNF protein levels in serum from patients suffering from different conditions.

Type: Article
Title: Brain-Derived Neurotrophic Factor in Patients with Huntington's Disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0022966
Publisher version: http://dx.doi.org/10.1371/journal.pone.0022966
Language: English
Additional information: © 2011 Zuccato et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This project was supported by the NeuroNE Sixth Framework Programme, European Union, LsHM-CT-2004-512039; the Stem-HD Sixth Framework Programme, European Union, LsHB-CT-2006-037349; and the CHDI Foundation (USA) to EC. Some of this work was undertaken at UCLH/UCL, which received a proportion of funding from the Department of Health's NIHR Biomedical Research Centres funding scheme. ACBL was supported by Gis - Maladies rares (A04159JS). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Keywords: FACTOR BDNF LEVELS, PERIPHERAL-BLOOD, HUMAN PLATELETS, SERUM, EXPRESSION, PLASMA, TRANSCRIPTION, DEPRESSION, BIOMARKERS, CEP-1347
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1318817
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