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Abnormal peripheral chemokine profile in Huntington's disease.

Wild, E; Magnusson, A; Lahiri, N; Krus, U; Orth, M; Tabrizi, SJ; Björkqvist, M; (2011) Abnormal peripheral chemokine profile in Huntington's disease. PLoS Curr , 1 10.1371/currents.RRN1231. Green open access

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Abstract

Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by both neurological and systemic abnormalities. Immune activation is a well-established feature of the HD brain and we have previously demonstrated a widespread, progressive innate immune response detectable in plasma throughout the course of HD. In the present work we used multiplex ELISA to quantify levels of chemokines in plasma from controls and subjects at different stages of HD. We found an altered chemokine profile tracking with disease progression, with significant elevations of five chemokines (eotaxin-3, MIP-1β, eotaxin, MCP-1 and MCP-4) while three (eotaxin-3, MIP-1β and eotaxin) showed significant linear increases across advancing disease stages. We validated our results in a separate sample cohort including subjects at different stages of HD. Here we saw that chemokine levels (MCP-1 and eotaxin) correlated with clinical scores. We conclude that, like cytokines, chemokines may be linked to the pathogenesis of HD, and that immune molecules may be valuable in tracking and exploring the pathogenesis of HD.

Type: Article
Title: Abnormal peripheral chemokine profile in Huntington's disease.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/currents.RRN1231
Publisher version: http://dx.doi.org/10.1371/currents.RRN1231
Language: English
Additional information: This study was financially supported by the CHDI Foundation, New York, and also funded in part by the UK Department of Health, the Medical Research Council (UK), the Wellcome Trust, BenteRexed foundation, Swedish research Council, Crafoord Foundation and The Royal Physiological Society.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1318816
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