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Changes in benzodiazepine receptor binding as seen autoradiographically in the central nervous system of the spastic mouse

Biscoe, TJ; Fry, JP; Rickets, C; (1984) Changes in benzodiazepine receptor binding as seen autoradiographically in the central nervous system of the spastic mouse. Journal of Physiology , 352 (1) pp. 509-516. 10.1113/jphysiol.1984.sp015306.

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Abstract

Quantitative light-microscope autoradiography has been used to compare the specific, clonazepam-displaceable binding of [3H]flunitrazepam, a photoaffinity label for the 1,4-benzodiazepine receptor, in different regions of the brain and spinal cord of spastic mice and their unaffected littermates. Specific binding of [3H]flunitrazepam in the central nervous system of the spastic mouse showed significant increases in the anterior colliculus and pretectal area and in all laminae of the grey matter in the lumbar spinal cord. These results confirm homogenate binding assays suggesting an increased number of benzodiazepine receptors in the spinal cord of the spastic mouse. Possible sites are therefore provided at which disorders of function could arise, associated with changes seen at the gamma-aminobutyric acid (GABA)-benzodiazepine receptor complex in spinal cord homogenates from the mutant mouse spastic.

Type: Article
Title: Changes in benzodiazepine receptor binding as seen autoradiographically in the central nervous system of the spastic mouse
Location: ENGLAND
DOI: 10.1113/jphysiol.1984.sp015306
Publisher version: http://dx.doi.org/10.1113/jphysiol.1984.sp015306
Language: English
Keywords: Animals, Autoradiography, Brain, Flunitrazepam, In Vitro Techniques, Male, Mice, Mice, Mutant Strains, Muscle Spasticity, Receptors, Cell Surface, Receptors, GABA-A, Spinal Cord
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: https://discovery.ucl.ac.uk/id/eprint/1318339
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