UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

An assessment of the quality of randomised controlled trials conducted in China

Zhang, DL; Yin, P; Freemantle, N; Jordan, R; Zhong, N; Cheng, KK; (2008) An assessment of the quality of randomised controlled trials conducted in China. Trials , 9 , Article 22. 10.1186/1745-6215-9-22. Green open access

[thumbnail of 1745-6215-9-22.pdf]
Preview
PDF
1745-6215-9-22.pdf

Download (261kB)

Abstract

Background: Despite the rapid increase in research in China, little is known about the quality of clinical trials conducted there.Methods: A systematic review and critical appraisal of randomised controlled trials (RCTs) conducted in China and published in 2004 was undertaken to describe their characteristics, assess the quality of their reporting, and where possible, the quality of their conduct. Randomised controlled trials in all disease areas and types of interventions, which took place in China and included Chinese citizens were identified using PubMed and hand searching the Journal Series of the Chinese Medical Association. Quality was assessed against a subset of criteria adapted from the CONSORT statement.Results: Three hundred and seven RCTs were included. One hundred and ninety-nine (64.8%) failed to report methods of randomization and 254 (82.4%) did not mention blinding of either participants or investigators. Reporting of baseline characteristics, primary outcome and length of follow-up was inadequate in a substantial proportion of studies. Fewer than 11% of RCTs mentioned ethical approval and only 18.0% adequately discussed informed consent. However, dropout rates were very favourable with nearly 44% of trials reporting a zero dropout rate.Conclusion: Reporting of RCTs in China requires substantial improvement to meet the targets of the CONSORT statement. The conduct of Chinese RCTs cannot be directly inferred from the standard of reporting; however without good reporting the methods of the trials cannot be clearly ascertained.

Type: Article
Title: An assessment of the quality of randomised controlled trials conducted in China
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1745-6215-9-22
Publisher version: http://dx.doi.org/10.1186/1745-6215-9-22
Language: English
Additional information: © 2008 Zhang et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Clinical-trials, consort statement, metaanalysis, medicine, journals
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > Comprehensive CTU at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/1315436
Downloads since deposit
118Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item