UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Cortical network for gaze control in humans revealed using multimodal MRI

Anderson, EJ; Jones, DK; O'Gorman, RL; Leemans, A; Catani, M; Husain, M; (2012) Cortical network for gaze control in humans revealed using multimodal MRI. Cerebral Cortex , 22 (4) 765 -775. 10.1093/cercor/bhr110. Green open access

[img]
Preview
PDF
Cereb._Cortex-2012-Anderson-765-75.pdf

Download (1MB)

Abstract

Functional magnetic resonance imaging (fMRI) techniques allow definition of cortical nodes that are presumed to be components of large-scale distributed brain networks involved in cognitive processes. However, very few investigations examine whether such functionally defined areas are in fact structurally connected. Here, we used combined fMRI and diffusion MRI-based tractography to define the cortical network involved in saccadic eye movement control in humans. The results of this multimodal imaging approach demonstrate white matter pathways connecting the frontal eye fields and supplementary eye fields, consistent with the known connectivity of these regions in macaque monkeys. Importantly, however, these connections appeared to be more prominent in the right hemisphere of humans. In addition, there was evidence of a dorsal frontoparietal pathway connecting the frontal eye field and the inferior parietal lobe, also right hemisphere dominant, consistent with specialization of the right hemisphere for directed attention in humans. These findings demonstrate the utility and potential of using multimodal imaging techniques to define large-scale distributed brain networks, including those that demonstrate known hemispheric asymmetries in humans.

Type: Article
Title: Cortical network for gaze control in humans revealed using multimodal MRI
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/cercor/bhr110
Publisher version: http://dx.doi.org/10.1093/cercor/bhr110
Language: English
Additional information: © The Authors 2011. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com PMCID: PMC3306571
Keywords: Adult, Algorithms, Attention, Brain mapping, Diffusion ensor Imaging, Female, Fixation, Ocular, Functional laterality, Humans, Image processing, Computer-assisted, Linear models, Magnetic Resonance Imaging, Male, Nerve net, Photic stimulation, Visual cortex, Visual fields, Visual pathways
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/1315157
Downloads since deposit
66Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item