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Auditory object cognition in dementia

Goll, JC; Kim, LG; Hailstone, JC; Lehmann, M; Buckley, A; Crutch, SJ; Warren, JD; (2011) Auditory object cognition in dementia. Neuropsychologia , 49 (9) 2755 - 2765. 10.1016/j.neuropsychologia.2011.06.004. Green open access

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Abstract

The cognition of nonverbal sounds in dementia has been relatively little explored. Here we undertook a systematic study of nonverbal sound processing in patient groups with canonical dementia syndromes comprising clinically diagnosed typical amnestic Alzheimer's disease (AD; n = 21), progressive nonfluent aphasia (PNFA; n = 5), logopenic progressive aphasia (LPA; n = 7) and aphasia in association with a progranulin gene mutation (GAA; n = 1), and in healthy age-matched controls (n = 20). Based on a cognitive framework treating complex sounds as 'auditory objects', we designed a novel neuropsychological battery to probe auditory object cognition at early perceptual (sub-object), object representational (apperceptive) and semantic levels. All patients had assessments of peripheral hearing and general neuropsychological functions in addition to the experimental auditory battery. While a number of aspects of auditory object analysis were impaired across patient groups and were influenced by general executive (working memory) capacity, certain auditory deficits had some specificity for particular dementia syndromes. Patients with AD had a disproportionate deficit of auditory apperception but preserved timbre processing. Patients with PNFA had salient deficits of timbre and auditory semantic processing, but intact auditory size and apperceptive processing. Patients with LPA had a generalised auditory deficit that was influenced by working memory function. In contrast, the patient with GAA showed substantial preservation of auditory function, but a mild deficit of pitch direction processing and a more severe deficit of auditory apperception. The findings provide evidence for separable stages of auditory object analysis and separable profiles of impaired auditory object cognition in different dementia syndromes. (C) 2011 Elsevier Ltd. All rights reserved.

Type: Article
Title: Auditory object cognition in dementia
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuropsychologia.2011.06.004
Publisher version: http://dx.doi.org/10.1016/j.neuropsychologia.2011....
Language: English
Additional information: © 2011 Elsevier
Keywords: Dementia, Auditory perception, Auditory object, PRIMARY-PROGRESSIVE-APHASIA, PURE WORD DEAFNESS, FRONTOTEMPORAL LOBAR DEGENERATION, WORKING-MEMORY TASKS, ALZHEIMERS-DISEASE, NEURAL REPRESENTATION, SEMANTIC DEMENTIA, PITCH PERCEPTION, NATURAL SOUNDS, SPEECH SOUNDS
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1315021
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