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Terahertz pulsed imaging of freshly excised human colonic tissues

Reid, CB; Fitzgerald, A; Reese, G; Goldin, R; Tekkis, P; O'Kelly, PS; Pickwell-MacPherson, E; ... Wallace, VP; + view all (2011) Terahertz pulsed imaging of freshly excised human colonic tissues. Physics in Medicine and Biology , 56 (14) 4333 - 4353. 10.1088/0031-9155/56/14/008. Green open access

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Abstract

We present the results from a feasibility study which measures properties in the terahertz frequency range of excised cancerous, dysplastic and healthy colonic tissues from 30 patients. We compare their absorption and refractive index spectra to identify trends which may enable different tissue types to be distinguished. In addition, we present statistical models based on variations between up to 17 parameters calculated from the reflected time and frequency domain signals of all the measured tissues. These models produce a sensitivity of 82% and a specificity of 77% in distinguishing between healthy and all diseased tissues and a sensitivity of 89% and a specificity of 71% in distinguishing between dysplastic and healthy tissues. The contrast between the tissue types was supported by histological staining studies which showed an increased vascularity in regions of increased terahertz absorption.

Type: Article
Title: Terahertz pulsed imaging of freshly excised human colonic tissues
Open access status: An open access version is available from UCL Discovery
DOI: 10.1088/0031-9155/56/14/008
Publisher version: http://dx.doi.org/10.1088/0031-9155/56/14/008
Language: English
Additional information: © 2011 Institute of Physics and Engineering in Medicine
Keywords: BASAL-CELL CARCINOMA, IN-VIVO, REFLECTION GEOMETRY, BREAST-TUMORS, EX-VIVO, SPECTROSCOPY, CLASSIFICATION, CANCER
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of the Built Environment
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of the Built Environment > Bartlett School Env, Energy and Resources
URI: https://discovery.ucl.ac.uk/id/eprint/1314658
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