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Pathogenicity of Misfolded and Dimeric HLA-B27 Molecules

Antoniou, AN; Lenart, I; Guiliano, DB; (2011) Pathogenicity of Misfolded and Dimeric HLA-B27 Molecules. International Journal of Rheumatology , 2011 486856 - ?. 10.1155/2011/486856. Green open access

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Abstract

The association between HLA-B27 and the group of autoimmune inflammatory arthritic diseases, the spondyloarthropathies (SpAs) which include ankylosing spondylitis (AS) and Reactive Arthritis (ReA), has been well established and remains the strongest association between any HLA molecule and autoimmune disease. The mechanism behind this striking association remains elusive; however animal model and biochemical data suggest that HLA-B27 misfolding may be key to understanding its association with the SpAs. Recent investigations have focused on the unusual biochemical structures of HLA-B27 and their potential role in SpA pathogenesis. Here we discuss how these unusual biochemical structures may participate in cellular events leading to chronic inflammation and thus disease progression.

Type: Article
Title: Pathogenicity of Misfolded and Dimeric HLA-B27 Molecules
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1155/2011/486856
Publisher version: http://dx.doi.org/10.1155/2011/486856
Language: English
Additional information: Copyright © 2011 Antony N. Antoniou et al. This is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/1314321
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