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MLL/GAS7 fusion in a pediatric case of t(11;17)(q23;p13)-positive precursor B-cell acute lymphoblastic leukemia

Panagopoulos, I; Lilljebjorn, H; Strombeck, B; Hjorth, L; Olofsson, T; Johansson, B; (2006) MLL/GAS7 fusion in a pediatric case of t(11;17)(q23;p13)-positive precursor B-cell acute lymphoblastic leukemia. Haematologica-Hematology Journal , 91 (9) 1287 - 1288. Green open access

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Abstract

AML/GAS7, resulting from t(11;17)(q23;p13), has been reported in one case of treatment-related acute myeloid leukemia (AML). We present a de novo case of t(11;17)-positive pediatric acute lymphoblastic leukemia. Fluorescent in situ hybridization and reverse transcriptase polymerase chain reaction analyses revealed an MLL/GAS7 chimera identical to the one previously described in AML. The molecular genetic features of MLL/GAS7 and the clinical impact of t(11;17) are discussed.

Type: Article
Title: MLL/GAS7 fusion in a pediatric case of t(11;17)(q23;p13)-positive precursor B-cell acute lymphoblastic leukemia
Open access status: An open access version is available from UCL Discovery
Publisher version: http://www.haematologica.org
Language: English
Additional information: This work is published under under a Creative Commons Attribution 3.0 License (CC BY 3.0): http://creativecommons.org/licenses/by/3.0/
Keywords: ALL, translocation, MLL, GAS7, fusion, MYELOID-LEUKEMIA, MLL/GRAF FUSION, CHEMOTHERAPY
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/1314071
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