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Pharmacokinetics of Mitomycin C Following Hepatic Arterial Chemoembolization With Gelfoam

Ding, JW; Wu, ZD; Andersson, R; Bengmark, S; (1992) Pharmacokinetics of Mitomycin C Following Hepatic Arterial Chemoembolization With Gelfoam. HPB Surg , 5 (3) 161 - 167. 10.1155/1992/67843. Green open access

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Abstract

Twelve mongrel dogs were randomly allocated into two groups using matched paired-design. Catheters were inserted into the hepatic artery, hepatic vein and the femoral vein, respectively. In the first group, gelfoam supplemented with mitomycin C (MMC) was injected into the hepatic artery, whereas the second group received a hepatic arterial injection of MMC solution alone. Simultaneous blood sampling from the hepatic and femoral vein at regular intervals was performed. MMC concentrations in plasma was determined using high performance liquid chromatography (HPLC) and the pharmacokinetics of MMC were determined. MMC concentrations in hepatic and femoral veins did not differ and no significant difference in pharmacokinetics was found when comparing MMC administration into the hepatic artery with or without gelfoam supplementation. Thus, our results revealed that gelfoam could not delay the clearance of MMC from the liver.

Type: Article
Title: Pharmacokinetics of Mitomycin C Following Hepatic Arterial Chemoembolization With Gelfoam
Location: SWITZERLAND
Open access status: An open access version is available from UCL Discovery
DOI: 10.1155/1992/67843
Publisher version: http://dx.doi.org/10.1155/1992/67843
Language: English
Additional information: Copyright © 1992 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Animals, Chemoembolization, Therapeutic, Dogs, Femoral Vein, Gelatin Sponge, Absorbable, Hepatic Artery, Hepatic Veins, Liver Neoplasms, Mitomycin, Random Allocation
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/1313450
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