UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Action Dominates Valence in Anticipatory Representations in the Human Striatum and Dopaminergic Midbrain

Guitart-Masip, M; Fuentemilla, L; Bach, DR; Huys, QJM; Dayan, P; Dolan, RJ; Duzel, E; (2011) Action Dominates Valence in Anticipatory Representations in the Human Striatum and Dopaminergic Midbrain. Journal of Neuroscience , 31 (21) 7867- 7875. 10.1523/JNEUROSCI.6376-10.2011. Green open access

[img]
Preview
PDF
7867.full.pdf

Download (1MB)

Abstract

The acquisition of reward and the avoidance of punishment could logically be contingent on either emitting or withholding particular actions. However, the separate pathways in the striatum for go and no-go appear to violate this independence, instead coupling affect and effect. Respect for this interdependence has biased many studies of reward and punishment, so potential action-outcome valence interactions during anticipatory phases remain unexplored. In a functional magnetic resonance imaging study with healthy human volunteers, we manipulated subjects' requirement to emit or withhold an action independent from subsequent receipt of reward or avoidance of punishment. During anticipation, in the striatum and a lateral region within the substantia nigra/ventral tegmental area (SN/VTA), action representations dominated over valence representations. Moreover, we did not observe any representation associated with different state values through accumulation of outcomes, challenging a conventional and dominant association between these areas and state value representations. In contrast, a more medial sector of the SN/VTA responded preferentially to valence, with opposite signs depending on whether action was anticipated to be emitted or withheld. This dominant influence of action requires an enriched notion of opponency between reward and punishment.

Type: Article
Title: Action Dominates Valence in Anticipatory Representations in the Human Striatum and Dopaminergic Midbrain
Open access status: An open access version is available from UCL Discovery
DOI: 10.1523/JNEUROSCI.6376-10.2011
Publisher version: http://dx.doi.org/10.1523/JNEUROSCI.6376-10.2011
Language: English
Additional information: This work is available to the public to copy, distribute, or display under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license (CC-BY-NC-SA).
Keywords: Nucleus-accumbens dopamine, Temporal difference models, Human brain, Reward representations, Conditioned avoidance, Response-inhibition, Prediction errors, Serotonin, Systems, Stimuli
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/1309576
Downloads since deposit
63Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item