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The effectiveness of early lens extraction with intraocular lens implantation for the treatment of primary angle-closure glaucoma (EAGLE): study protocol for a randomized controlled trial

Azuara-Blanco, A; Burr, JM; Cochran, C; Ramsay, C; Vale, L; Foster, P; Friedman, D; ... Effectiveness in Angle-closure Glaucoma of Lens Extraction (EAGL; + view all (2011) The effectiveness of early lens extraction with intraocular lens implantation for the treatment of primary angle-closure glaucoma (EAGLE): study protocol for a randomized controlled trial. Trials , 12 , Article 133. 10.1186/1745-6215-12-133. Green open access

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Abstract

Glaucoma is the leading cause of irreversible blindness. Although primary open-angle glaucoma is more common, primary angle-closure glaucoma (PACG) is more likely to result in irreversible blindness. By 2020, 5·3 million people worldwide will be blind because of PACG. The current standard care for PACG is a stepped approach of a combination of laser iridotomy surgery (to open the drainage angle) and medical treatment (to reduce intraocular pressure). If these treatments fail, glaucoma surgery (eg, trabeculectomy) is indicated. It has been proposed that, because the lens of the eye plays a major role in the mechanisms leading to PACG, early clear lens extraction will improve glaucoma control by opening the drainage angle. This procedure might reduce the need for drugs and glaucoma surgery, maintain good visual acuity, and improve quality of life compared with standard care.EAGLE aims to evaluate whether early lens extraction improves patient-reported, clinical outcomes, and cost-effectiveness, compared with standard care.

Type: Article
Title: The effectiveness of early lens extraction with intraocular lens implantation for the treatment of primary angle-closure glaucoma (EAGLE): study protocol for a randomized controlled trial
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1745-6215-12-133
Publisher version: http://dx.doi.org/10.1186/1745-6215-12-133
Language: English
Additional information: © 2011 Azuara-Blanco et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. PMCID: PMC3121608
Keywords: Asia, Cost-Benefit Analysis, Glaucoma, Angle-Closure, Great Britain, Health Care Costs, Humans, Intraocular Pressure, Lens Implantation, Intraocular, Lens, Crystalline, Lenses, Intraocular, Middle Aged, Ophthalmic Solutions, Phacoemulsification, Quality of Life, Questionnaires, Recovery of Function, Research Design, Time Factors, Trabeculectomy, Treatment Outcome, Vision, Ocular, Visual Acuity, Visual Fields
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/1309563
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