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The effect of cannabis use and cognitive reserve on age at onset and psychosis outcomes in first-episode schizophrenia

Leeson, VC; Harrison, I; Ron, MA; Barnes, TR; Joyce, EM; (2012) The effect of cannabis use and cognitive reserve on age at onset and psychosis outcomes in first-episode schizophrenia. Schizophrenia Bulletin , 38 (4) 873 - 880. 10.1093/schbul/sbq153. Green open access

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Abstract

Cannabis use is associated with a younger age at onset of psychosis, an indicator of poor prognosis, but better cognitive function, a positive prognostic indicator. We aimed to clarify the role of age at onset and cognition on outcomes in cannabis users with first-episode schizophrenia as well as the effect of cannabis dose and cessation of use.

Type: Article
Title: The effect of cannabis use and cognitive reserve on age at onset and psychosis outcomes in first-episode schizophrenia
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/schbul/sbq153
Publisher version: http://dx.doi.org/10.1093/schbul/sbq153
Language: English
Additional information: © The Authors 2011. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. PMCID: PMC3406524
Keywords: Adolescent, Adult, Age of onset, Cognitive reserve, Disease progression, Female, Humans, Male, Marijuana smoking, Precipitating factors, Prodromal symptoms, Prognosis, Psychotic disorders, Schizophrenia, Social adjustment
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: https://discovery.ucl.ac.uk/id/eprint/1309496
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