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Memory Consolidation in the Cerebellar Cortex

Kellett, DO; Fukunaga, I; Chen-Kubota, E; Dean, P; Yeo, CH; (2010) Memory Consolidation in the Cerebellar Cortex. PLOS ONE , 5 (7) , Article e11737. 10.1371/journal.pone.0011737. Green open access

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Abstract

Several forms of learning, including classical conditioning of the eyeblink, depend upon the cerebellum. In examining mechanisms of eyeblink conditioning in rabbits, reversible inactivations of the control circuitry have begun to dissociate aspects of cerebellar cortical and nuclear function in memory consolidation. It was previously shown that post-training cerebellar cortical, but not nuclear, inactivations with the GABA(A) agonist muscimol prevented consolidation but these findings left open the question as to how final memory storage was partitioned across cortical and nuclear levels. Memory consolidation might be essentially cortical and directly disturbed by actions of the muscimol, or it might be nuclear, and sensitive to the raised excitability of the nuclear neurons following the loss of cortical inhibition. To resolve this question, we simultaneously inactivated cerebellar cortical lobule HVI and the anterior interpositus nucleus of rabbits during the post-training period, so protecting the nuclei from disinhibitory effects of cortical inactivation. Consolidation was impaired by these simultaneous inactivations. Because direct application of muscimol to the nuclei alone has no impact upon consolidation, we can conclude that post-training, consolidation processes and memory storage for eyeblink conditioning have critical cerebellar cortical components. The findings are consistent with a recent model that suggests the distribution of learning-related plasticity across cortical and nuclear levels is task-dependent. There can be transfer to nuclear or brainstem levels for control of high-frequency responses but learning with lower frequency response components, such as in eyeblink conditioning, remains mainly dependent upon cortical memory storage.

Type: Article
Title: Memory Consolidation in the Cerebellar Cortex
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0011737
Publisher version: http://dx.doi.org/10.1371/journal.pone.0011737
Language: English
Additional information: © 2010 Kellett et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This work was supported by the Biotechnology and Biological Sciences Research Council, UK, http://www.bbsrc.ac.uk/, Grant No. BBS/B/16984. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Keywords: CONDITIONED EYELID RESPONSES, NICTITATING-MEMBRANE RESPONSES, VESTIBULOOCULAR REFLEX, PURKINJE-CELL, INFERIOR OLIVE, MOTOR CONTROL, PLASTICITY, ACQUISITION, EXTINCTION, NUCLEI
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: https://discovery.ucl.ac.uk/id/eprint/130854
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