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ParkDB: a Parkinson's disease gene expression database

Taccioli, C; Maselli, V; Tegnér, J; Gomez-Cabrero, D; Altobelli, G; Emmett, W; Lescai, F; ... Stupka, E; + view all (2011) ParkDB: a Parkinson's disease gene expression database. Database , 2011 (May 20) , Article bar007. 10.1093/database/bar007. Green open access

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Abstract

Parkinson's disease (PD) is a common, adult-onset, neuro-degenerative disorder characterized by the degeneration of cardinal motor signs mainly due to the loss of dopaminergic neurons in the substantia nigra. To date, researchers still have limited understanding of the key molecular events that provoke neurodegeneration in this disease. Here, we present ParkDB, the first queryable database dedicated to gene expression in PD. ParkDB contains a complete set of re-analyzed, curated and annotated microarray datasets. This resource enables scientists to identify and compare expression signatures involved in PD and dopaminergic neuron differentiation under different biological conditions and across species. Database URL: http://www2.cancer.ucl.ac.uk/Parkinson_Db2/

Type: Article
Title: ParkDB: a Parkinson's disease gene expression database
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/database/bar007
Publisher version: http://dx.doi.org/10.1093/database/bar007
Language: English
Additional information: This is Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. PMCID: PMC3098727
Keywords: Databases, Genetic, Gene Expression Regulation, Humans, Molecular Sequence Annotation, Parkinson Disease
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/1307450
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