Taccioli, C;
Maselli, V;
Tegnér, J;
Gomez-Cabrero, D;
Altobelli, G;
Emmett, W;
Lescai, F;
... Stupka, E; + view all
(2011)
ParkDB: a Parkinson's disease gene expression database.
Database
, 2011
(May 20)
, Article bar007. 10.1093/database/bar007.
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Abstract
Parkinson's disease (PD) is a common, adult-onset, neuro-degenerative disorder characterized by the degeneration of cardinal motor signs mainly due to the loss of dopaminergic neurons in the substantia nigra. To date, researchers still have limited understanding of the key molecular events that provoke neurodegeneration in this disease. Here, we present ParkDB, the first queryable database dedicated to gene expression in PD. ParkDB contains a complete set of re-analyzed, curated and annotated microarray datasets. This resource enables scientists to identify and compare expression signatures involved in PD and dopaminergic neuron differentiation under different biological conditions and across species. Database URL: http://www2.cancer.ucl.ac.uk/Parkinson_Db2/
| Type: | Article |
|---|---|
| Title: | ParkDB: a Parkinson's disease gene expression database |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/database/bar007 |
| Publisher version: | http://dx.doi.org/10.1093/database/bar007 |
| Language: | English |
| Additional information: | This is Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. PMCID: PMC3098727 |
| Keywords: | Databases, Genetic, Gene Expression Regulation, Humans, Molecular Sequence Annotation, Parkinson Disease |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1307450 |
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