Starkov, P;
Sheppard, TD;
(2011)
Borate esters as convenient reagents for direct amidation of carboxylic acids and transamidation of primary amides.
Organic and Biomolecular Chemistry
, 9
(5)
1320 - 1323.
10.1039/c0ob01069c.
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Abstract
Simple borates serve as effective promoters for amide bond formation with a variety of carboxylic acids and amines. With trimethyl or tris(2,2,2-trifluoroethyl) borate, amides are obtained in good to excellent yield and high purity after a simple work-up procedure. Tris(2,2,2-trifluoroethyl) borate can also be used for the straightforward conversion of primary amides to secondary amides via transamidation.
| Type: | Article |
|---|---|
| Title: | Borate esters as convenient reagents for direct amidation of carboxylic acids and transamidation of primary amides |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/c0ob01069c |
| Publisher version: | http://dx.doi.org/10.1039/c0ob01069c |
| Language: | English |
| Additional information: | Starkov, P and Sheppard, TD (2011) Borate esters as convenient reagents for direct amidation of carboxylic acids and transamidation of primary amides. Organic and Biomolecular Chemistry , 9 (5) 1320 - 1323. Reproduced by permission of The Royal Society of Chemistry |
| Keywords: | BOND FORMATION, CATALYTIC TRANSAMIDATION, AMINES, ALCOHOLS, CARBOXAMIDES, ACTIVATION, CHEMISTRY, ECONOMY |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1299951 |
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