UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

1,000 structures and more from the MCSG

Lee, D; de Beer, TAP; Laskowski, RA; Thornton, JM; Orengo, CA; (2011) 1,000 structures and more from the MCSG. BMC STRUCT BIOL , 11 , Article 2. 10.1186/1472-6807-11-2. Green open access

[img]
Preview
PDF
1472-6807-11-2.pdf

Download (1MB)

Abstract

Background: The Midwest Center for Structural Genomics (MCSG) is one of the large-scale centres of the Protein Structure Initiative (PSI). During the first two phases of the PSI the MCSG has solved over a thousand protein structures. A criticism of structural genomics is that target selection strategies mean that some structures are solved without having a known function and thus are of little biomedical significance. Structures of unknown function have stimulated the development of methods for function prediction from structure.Results: We show that the MCSG has met the stated goals of the PSI and use online resources and readily available function prediction methods to provide functional annotations for more than 90% of the MCSG structures. The structure-to-function prediction method ProFunc provides likely functions for many of the MCSG structures that cannot be annotated by sequence-based methods.Conclusions: Although the focus of the PSI was structural coverage, many of the structures solved by the MCSG can also be associated with functional classes and biological roles of possible biomedical value.

Type: Article
Title: 1,000 structures and more from the MCSG
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1472-6807-11-2
Publisher version: http://www.biomedcentral.com/1472-6807/11/2
Language: English
Additional information: © 2011 Lee et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: HIDDEN MARKOV-MODELS, PROTEIN DATA-BANK, FUNCTION PREDICTION, 3D TEMPLATES, FAMILY SPACE, GENOMICS, DATABASE, DOMAIN, TOOL, CLASSIFICATION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: https://discovery.ucl.ac.uk/id/eprint/1298906
Downloads since deposit
80Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item