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Mitophagy and Parkinson's disease: The PINK1–parkin link

Deas, E; Wood, NW; Plun-Favreau, H; (2011) Mitophagy and Parkinson's disease: The PINK1–parkin link. [Review]. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research , 1813 (4) 623 - 633. 10.1016/j.bbamcr.2010.08.007. Green open access

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Abstract

The study of rare, inherited mutations underlying familial forms of Parkinson's disease has provided insight into the molecular mechanisms of disease pathogenesis. Mutations in these genes have been functionally linked to several key molecular pathways implicated in other neurodegenerative disorders, including mitochondrial dysfunction, protein accumulation and the autophagic-lysosomal pathway. In particular, the mitochondrial kinase PINK1 and the cytosolic E3 ubiquitin ligase parkin act in a common pathway to regulate mitochondrial function. In this review we discuss the recent evidence suggesting that the PINK1/parkin pathway also plays a critical role in the autophagic removal of damaged mitochondria–mitophagy. This article is part of a Special Issue entitled Mitochondria: the deadly organelle.

Type: Article
Title: Mitophagy and Parkinson's disease: The PINK1–parkin link
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.bbamcr.2010.08.007
Publisher version: https://doi.org/10.1016/j.bbamcr.2010.08.007
Language: English
Additional information: © 2010 Elsevier B.V. This version of record is made available under the CC BY 4.0 licence [https://creativecommons.org/licenses/by/4.0/]
Keywords: Mitochondria, Mitophagy, Neurodegeneration, Parkinson's disease, Parkin, PINK1
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/129877
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