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Retinal specific measurement of dark-adapted visual function: validation of a modified microperimeter

Crossland, MD; Luong, VA; Rubin, GS; Fitzke, FW; (2011) Retinal specific measurement of dark-adapted visual function: validation of a modified microperimeter. BMC Ophthalmology , 11 , Article 5. 10.1186/1471-2415-11-5. Green open access

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Abstract

Background: Scotopic function is an important marker of many retinal diseases and is increasingly used as an outcome measure in clinical trials, such as those investigating gene therapy for Lebers congenital amaurosis. Scotopic visual function has traditionally been measured using an adapted perimetry system such as the Humphrey field analyser (HFA). However this system does not control for fixation errors or poor fixation stability. Here we evaluate the use of an adapted microperimeter to measure visual function at defined retinal regions under scotopic conditions.Methods: A MP-1 microperimeter (Nidek Technologies, Italy) was modified by adding a 1 log unit Neutral Density filter and a 530nm shortpass filter within the optical path of the instrument. Stray light was shielded. Fine matrix mapping perimetry was performed on five younger (<35 years) and five older (>65 years) subjects with no eye disease and good vision. All subjects were fully dark adapted before testing and pupils were dilated with 1% tropicamide. Tests was performed once on the modified MP-1 microperimeter and once using a modified HFA, in a counterbalanced order.Results: A foveal scotopic scotoma with a sensitivity reduction of >1 log unit was found using each instrument. In addition, the MP-1 system showed the retinal location of the foveal scotoma. Mean test time was 25 minutes for the MP-1 and 32 minutes for the HFA.Discussion: A modified MP-1 microperimeter can be used to measure scotopic retinal function, creating results which are comparable to the modified Humphrey field analyser. Advantages of the MP-1 system include the ability to track the retina through testing, retinal localisation of the scotoma and a faster test time.

Type: Article
Title: Retinal specific measurement of dark-adapted visual function: validation of a modified microperimeter
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1471-2415-11-5
Publisher version: http://www.biomedcentral.com/1471-2415/11/5/
Language: English
Additional information: © 2011 Crossland et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: AGE-RELATED MACULOPATHY, RETINITIS-PIGMENTOSA, MACULAR DEGENERATION, FUNDUS AUTOFLUORESCENCE, ROD, ADAPTATION, PERIMETRY, SENSITIVITY, RESPONSES, GOLDMANN
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/1298618
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