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In vitro biocompatibility and mechanical performance of titanium doped high calcium oxide metaphosphate-based glasses

Abou Neel, EA; Chrzanowski, W; Georgiou, G; Dalby, MJ; Knowles, JC; (2010) In vitro biocompatibility and mechanical performance of titanium doped high calcium oxide metaphosphate-based glasses. Journal of Tissue Engineering , 2010 , Article 390127. 10.4061/2010/390127. Green open access

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Abstract

This study challenged to produce phosphate-based glasses (PBG) for the treatment of osseous defects. The glasses contained, among other components, 40 mol% CaO and 1-5 mol% TiO(2). The mechanical performance and in vitro biocompatibility using both human osteosarcoma and primary osteoblasts were carried out. Incorporation of TiO(2) into PBG had no significant effect on strength and modulus. These glasses encouraged attachment and maintained high viability of osteosarcoma cells similar to the positive control surface. Cells grown directly (on glasses) or indirectly (in the presence of glass extracts) showed similar proliferation pattern to the positive control cells with no significant effect of TiO(2) detected. Increasing TiO(2) content, however, has a profound effect on cytoskeleton organization and spreading and maturation of primary osteoblasts. It is believed that TiO(2) might have acted as a chemical cue-modulating cells response, and hence the substrates supported maturation/mineralization of the primary osteoblasts.

Type: Article
Title: In vitro biocompatibility and mechanical performance of titanium doped high calcium oxide metaphosphate-based glasses
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.4061/2010/390127
Publisher version: http://dx.doi.org/10.4061/2010/390127
Language: English
Additional information: Copyright © 2010 Ensanya A. Abou Neel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. PMCID: PMC3042677
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1298565
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