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Targeted Regeneration of Bone in the Osteoporotic Human Femur

Poole, KES; Treece, GM; Ridgway, GR; Mayhew, PM; Borggrefe, J; Gee, AH; (2011) Targeted Regeneration of Bone in the Osteoporotic Human Femur. PLOS ONE , 6 (1) , Article e16190. 10.1371/journal.pone.0016190. Green open access

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Abstract

We have recently developed image processing techniques for measuring the cortical thicknesses of skeletal structures in vivo, with resolution surpassing that of the underlying computed tomography system. The resulting thickness maps can be analysed across cohorts by statistical parametric mapping. Applying these methods to the proximal femurs of osteoporotic women, we discover targeted and apparently synergistic effects of pharmaceutical osteoporosis therapy and habitual mechanical load in enhancing bone thickness.

Type: Article
Title: Targeted Regeneration of Bone in the Osteoporotic Human Femur
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0016190
Publisher version: http://dx.doi.org/10.1371/journal.pone.0016190
Language: English
Additional information: © 2011 Poole et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This work was supported by an Arthritis Research UK Clinician Scientist Fellowship award to KESP (The FEMCO study, ARC17822, http://www.arthritisresearchuk.org/) and by the Cambridge Biomedical Research Centre (National Institute for Health Research), an institutional award that supports PMM. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. KESP and GMT are inventors on a related Great Britain patent application GB0917524.1, "Image data processing systems." This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.
Keywords: REGISTRATION, DENSITY
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/1298507
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