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Pain Genes

Foulkes, T; Wood, JN; (2008) Pain Genes. PLoS Genetics , 4 (7) , Article e1000086. 10.1371/journal.pgen.1000086. Green open access

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Abstract

Pain, which afflicts up to 20% of the population at any time, provides both a massive therapeutic challenge and a route to understanding mechanisms in the nervous system. Specialised sensory neurons (nociceptors) signal the existence of tissue damage to the central nervous system (CNS), where pain is represented in a complex matrix involving many CNS structures. Genetic approaches to investigating pain pathways using model organisms have identified the molecular nature of the transducers, regulatory mechanisms involved in changing neuronal activity, as well as the critical role of immune system cells in driving pain pathways. In man, mapping of human pain mutants as well as twin studies and association studies of altered pain behaviour have identified important regulators of the pain system. In turn, new drug targets for chronic pain treatment have been validated in transgenic mouse studies. Thus, genetic studies of pain pathways have complemented the traditional neuroscience approaches of electrophysiology and pharmacology to give us fresh insights into the molecular basis of pain perception.

Type: Article
Title: Pain Genes
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pgen.1000086
Publisher version: http://dx.doi.org/10.1371/journal.pgen.1000086
Language: English
Additional information: © 2008 Foulkes, Wood. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: QUANTITATIVE TRAIT LOCI, DORSAL-ROOT GANGLIA, HEREDITARY SENSORY NEUROPATHY, CHANNEL ALPHA-SUBUNIT, INSECT SODIUM-CHANNEL, INBRED MOUSE STRAINS, OPIOID RECEPTOR GENE, MORPHINE ANTINOCICEPTION, CAPSAICIN RECEPTOR, INFLAMMATORY PAIN
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: https://discovery.ucl.ac.uk/id/eprint/126496
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