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Accuracy and resolution of THz reflection spectroscopy for medical imaging

Reid, CB; Pickwell-MacPherson, E; Laufer, JG; Gibson, AP; Hebden, JC; Wallace, VP; (2010) Accuracy and resolution of THz reflection spectroscopy for medical imaging. Physics in Medicine and Biology , 55 (16) 4825 - 4838. 10.1088/0031-9155/55/16/013. Green open access

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Abstract

The use of THz radiation as a potential tool for medical imaging is of increasing interest. In this paper threemethods of analysis of THz spectroscopic information for diagnosis of tissue pathologies at THz frequencies are presented. The frequency-dependent absorption coefficients, refractive indices and Debye relaxation times of pure water and pure lipids were measured and used as prior knowledge in the different theoretical methods for the determination of concentration. Three concentration analysis methods were investigated: (a) linear spectral decomposition, (b) spectrally averaged dielectric coefficient method and (c) the Debye relaxation coefficient method. These methods were validated on water and lipid emulsions by determining the concentrations of phantom chromophores and comparing to the known composition. The accuracy and resolution of each method were determined to assess the potential of each method as a tool for medical diagnosis at THz frequencies.

Type: Article
Title: Accuracy and resolution of THz reflection spectroscopy for medical imaging
Open access status: An open access version is available from UCL Discovery
DOI: 10.1088/0031-9155/55/16/013
Publisher version: http://dx.doi.org/10.1088/0031-9155/55/16/013
Language: English
Additional information: © 2010 Institute of Physics and Engineering in Medicine
Keywords: TERAHERTZ PULSED SPECTROSCOPY, TIME-DOMAIN SPECTROSCOPY, BASAL-CELL CARCINOMA, TECHNOLOGY, GEOMETRY, CANCER, TISSUE, RANGE
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of the Built Environment
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of the Built Environment > Bartlett School Env, Energy and Resources
URI: https://discovery.ucl.ac.uk/id/eprint/126336
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