UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

The discovery of endogenous retroviruses

Weiss, RA; (2006) The discovery of endogenous retroviruses. Retrovirology , 3 , Article 67. 10.1186/1742-4690-3-67. Green open access

[thumbnail of Weiss_endogenous_retroviruses_2006_1742-4690-3-67.pdf]
Preview
PDF
Weiss_endogenous_retroviruses_2006_1742-4690-3-67.pdf

Download (371kB)

Abstract

When endogenous retroviruses (ERV) were discovered in the late 1960s, the Mendelian inheritance of retroviral genomes by their hosts was an entirely new concept. Indeed Howard M Temin's DNA provirus hypothesis enunciated in 1964 was not generally accepted, and reverse transcriptase was yet to be discovered. Nonetheless, the evidence that we accrued in the pre-molecular era has stood the test of time, and our hypothesis on ERV, which one reviewer described as 'impossible', proved to be correct. Here I recount some of the key observations in birds and mammals that led to the discovery of ERV, and comment on their evolution, cross-species dispersion, and what remains to be elucidated.

Type: Article
Title: The discovery of endogenous retroviruses
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1742-4690-3-67
Publisher version: http://dx.doi.org/10.1186/1742-4690-3-67
Language: English
Additional information: © 2006 Weiss; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Rous sarcoma virus, Avian-leukosis virus, Murine leukemia-virus, Dependent DNA polymerase, RNA tumor-viruses, Mammary-tumor, Reticuloendotheliosis-virus, Cellular susceptibility, Envelope protein, Genetic control
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: https://discovery.ucl.ac.uk/id/eprint/125995
Downloads since deposit
74Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item