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Axonal damage markers in cerebrospinal fluid are increased in ALS

Brettschneider, J; Petzold, A; Sussmuth, SD; Ludolph, AC; Tumani, H; (2006) Axonal damage markers in cerebrospinal fluid are increased in ALS. Neurology , 66 (6) 852 - 856. 10.1212/01.wnl.0000203120.85850.54.

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Abstract

OBJECTIVE: To test whether biomarkers for axonal degeneration correlated with clinical subtypes and were of use in predicting progression of ALS. METHODS: Patients with ALS (n = 69), patients with Alzheimer disease (AD; n = 73), and age-matched controls (n = 33) were included in this prospective study. CSF levels of tau protein and neurofilaments (NfH(SMI35)) were measured using ELISA. In 49 patients with ALS, follow-up data were available (median follow-up 7 months). RESULTS: CSF levels of NfHSMI35 were five times higher in patients with ALS (1.7 ng/mL) than in controls (0.3 ng/mL, p < 0.001) and 10 times higher than in patients with AD (0.14 ng/mL, p < 0.001). NfH(SMI35) values were also higher in patients with upper motor neuron-dominant ALS than in patients with typical ALS (upper motor neuron + lower motor neuron) at p = 0.02. Values of NfH(SMI35) were higher in ALS of more rapid progression. The values of NfH and tau did not correlate with CSF protein content. CONCLUSIONS: The authors propose that axonal damage markers in CSF may discriminate between subtypes of ALS and that they could be used as markers for therapeutic trials. CSF NfH was superior to tau in these discriminations.

Type: Article
Title: Axonal damage markers in cerebrospinal fluid are increased in ALS
DOI: 10.1212/01.wnl.0000203120.85850.54
Publisher version: https://doi.org/10.1212/01.wnl.0000203120.85850.54
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
URI: https://discovery.ucl.ac.uk/id/eprint/121578
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