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Visual recovery after perinatal stroke evidenced by functional and diffusion MRI: case report

Seghier, ML; Lazeyras, F; Zimine, S; Saudan-Frei, S; Safran, AB; Huppi, PS; (2005) Visual recovery after perinatal stroke evidenced by functional and diffusion MRI: case report. BMC Neurology , 5 , Article 17. 10.1186/1471-2377-5-17. Green open access

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Abstract

Background: After perinatal brain injury, clinico-anatomic correlations of functional deficits and brain plasticity remain difficult to evaluate clinically in the young infant. Thus, new non-invasive methods capable of early functional diagnosis are needed in young infants.Case Presentation: The visual system recovery in an infant with perinatal stroke is assessed by combining diffusion tensor imaging (DTI) and event-related functional MRI (ER-fMRI). All experiments were done at 1.5T. A first DTI experiment was performed at 12 months of age. At 20 months of age, a second DTI experiment was performed and combined with an ER-fMRI experiment with visual stimuli (2 Hz visual flash). At 20 months of age, ER-fMRI showed significant negative activation in the visual cortex of the injured left hemisphere that was not previously observed in the same infant. DTI maps suggest recovery of the optic radiation in the vicinity of the lesion. Optic radiations in the injured hemisphere are more prominent in DTI at 20 months of age than in DTI at 12 months of age.Conclusion: Our data indicate that functional cortical recovery is supported by structural modifications that concern major pathways of the visual system. These neuroimaging findings might contribute to elaborate a pertinent strategy in terms of diagnosis and rehabilitation.

Type: Article
Title: Visual recovery after perinatal stroke evidenced by functional and diffusion MRI: case report
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1471-2377-5-17
Publisher version: http://dx.doi.org/10.1186/1471-2377-5-17
Language: English
Additional information: © 2005 Seghier et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: LATERAL GENICULATE-NUCLEUS, NORMAL BRAIN MATURATION, WHITE-MATTER, MULTIPLE-SCLEROSIS, PHOTIC-STIMULATION, PRETERM INFANTS, FMRI DATA, TENSOR, CORTEX, CHILDREN
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/119920
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