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Food patterns associated with blood lipids are predictive of coronary heart disease: the Whitehall II study

McNaughton, SA; Mishra, GD; Brunner, EJ; (2009) Food patterns associated with blood lipids are predictive of coronary heart disease: the Whitehall II study. BRIT J NUTR , 102 (4) 619 - 624. 10.1017/S0007114509243030. Green open access

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Abstract

Analysis of the epidemiological effects of overall dietary patterns offers an alternative approach to the investigation of the role of diet in CHD. We analysed the role of blood lipid-related dietary patterns using a two-step method to confirm the prospective association of dietary pattern with incident CHD. Analysis is based on 7314 participants of the Whitehall II study. Dietary intake was measured using a 127-item FFQ. Reduced rank regression (RRR) was used to derive dietary pattern scores using baseline serum total and HDL-cholesterol, and TAG levels as dependent variables. Cox proportional hazard regression was used to confirm the association between dietary patterns and incident CHD (n 243) over 15 years of follow-up. Increased CHD risk (hazard ratio (HR) for top quartile: 2.01 (95% CI 1.41, 2.85) adjusted for age, sex, ethnicity and energy misreporting) was observed with a diet characterised by high consumption of white bread, fried potatoes, sugar in tea and coffee, burgers and sausages, soft drinks, and low consumption of French dressing and vegetables. The diet-CHD relationship was attenuated after adjustment for employment grade and health behaviours (HR for top quartile: 1.81; 95 % CI 1.26, 2.62), and further adjustment for blood pressure and BMI (HR for top quartile: 1.57; 95 % CI 1.08, 2.27). Dietary patterns are associated with serum lipids and predict CHD risk after adjustment for confounders. RRR identifies dietary patterns using prior knowledge and focuses on the pathways through which diet may influence disease. The present study adds to the evidence that diet is an important risk factor for CHD.

Type: Article
Title: Food patterns associated with blood lipids are predictive of coronary heart disease: the Whitehall II study
Open access status: An open access version is available from UCL Discovery
DOI: 10.1017/S0007114509243030
Publisher version: http://dx.doi.org/10.1017/S0007114509243030
Language: English
Additional information: © The Authors 2009
Keywords: Dietary patterns, Lipids, Coronary heart disease, Prospective cohort studies, Whitehall II study, PROSPECTIVE WEIGHT CHANGE, DIETARY PATTERNS, CARDIOVASCULAR-DISEASE, METABOLIC SYNDROME, ATHEROSCLEROSIS MESA, RISK-FACTORS, MORTALITY, METAANALYSIS, CHOLESTEROL, LIPOPROTEIN
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: https://discovery.ucl.ac.uk/id/eprint/118372
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