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Distribution of [3H]trans-resveratrol in rat tissues following oral administration

El-Mohsen, MA; Bayele, H; Kuhnle, G; Gibson, G; Debnam, E; Srai, SK; Rice-Evans, C; (2006) Distribution of [3H]trans-resveratrol in rat tissues following oral administration. BRIT J NUTR , 96 (1) 62 - 70. 10.1079/BJN20061810. Green open access

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Abstract

Resveratrol has been widely investigated for its potential health properties, although little is known about its metabolism in vivo. Here we investigated the distribution of metabolic products of [H-3]trans-resveratrol, following gastric administration. At 2 h, plasma concentrations reached 1 center dot 7 % of the administered dose, whilst liver and kidney concentrations achieved 1 center dot 0 and 0 center dot 6 %, respectively. Concentrations detected at 18 h were lower, being only 0 center dot 5 % in plasma and a total of 0 center dot 35 % in tissues. Furthermore, whilst kidney and liver concentrations fell to 10 and 25 %, respectively, of concentrations at 2 h, the brain retained 43 % of that measured at 2 h. Resveratrol-glucuronide was identified as the major metabolite, reaching 7 mu m in plasma at 2 h. However, at 18 h the main form identified in liver, heart, lung and brain was native resveratrol aglycone, indicating that it is the main form retained in the tissues. No phenolic degradation products were detected in urine or tissues, indicating that, unlike flavonoids, resveratrol does not appear to serve as a substrate for colonic microflora. The present study provides additional information about the nature of resveratrol metabolites and which forms might be responsible for its in vivo biological effects.

Type: Article
Title: Distribution of [3H]trans-resveratrol in rat tissues following oral administration
Open access status: An open access version is available from UCL Discovery
DOI: 10.1079/BJN20061810
Publisher version: http://dx.doi.org/10.1079/BJN20061810
Language: English
Additional information: © The Authors 2006
Keywords: resveratrol, metabolism, polyphenol, radioactive, distribution, TRANS-RESVERATROL, METABOLISM, HUMANS, POLYPHENOLS, ABSORPTION, WINE, BIOAVAILABILITY, DERIVATIVES, ACID
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: https://discovery.ucl.ac.uk/id/eprint/116583
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