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Analysis of potential transcriptomic biomarkers for Huntington's disease in peripheral blood

Runne, H; Kuhn, A; Wild, EJ; Pratyaksha, W; Kristiansen, M; Isaacs, JD; Regulier, E; ... Luthi-Carter, R; + view all (2007) Analysis of potential transcriptomic biomarkers for Huntington's disease in peripheral blood. Proceedings of the National Academy of Sciences , 104 (36) 14424 - 14429. 10.1073/pnas.0703652104. Green open access

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Abstract

Highly quantitative biomarkers of neuroclegenerative disease remain an important need in the urgent quest for disease-modifying therapies. For Huntington's disease (HD), a genetic test is available (trait marker), but necessary state markers are still in development. in this report, we describe a large battery of transcriptomic tests explored as state biomarker candidates. In an attempt to exploit the known neuroinflarnmatory and transcriptional perturbations of disease, we measured relevant mRNAs in peripheral blood cells. The performance of these potential markers was weak overall, with only one mRNA, immediate early response 3 (IER3), showing a modest but significant increase of 32% in HD samples compared with controls. No statistically significant differences were found for any other mRNAs tested, including a panel of 12 RNA biomarkers identified in a previous report [Borovecki F, Lovrecic L, Zhou J, Jeong H, Then F, Rosas HID, Hersch SM, Hogarth P, Bouzou B, Jensen RV, et al. (2005) Proc Nad Acad Sci USA 102:11023-11028]. The present results may nonetheless inform the future design and testing of HD biomarker strategies.

Type: Article
Title: Analysis of potential transcriptomic biomarkers for Huntington's disease in peripheral blood
Open access status: An open access version is available from UCL Discovery
DOI: 10.1073/pnas.0703652104
Publisher version: http://dx.doi.org/10.1073/pnas.0703652104
Language: English
Keywords: state biomarker, RNA biomarker, gene expression profiling, polyglutamine disease, neurodegenerative disease, gene-expression, probe level, predict-hd, brain, dysregulation, normalization, therapeutics, complement, activation, microglia
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Genetics and Genomic Medicine Dept
URI: https://discovery.ucl.ac.uk/id/eprint/116285
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