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Pathogen burden and cortisol profiles over the day

Steptoe, A; Gylfe, A; Shamaei-Tousi, A; Bergstrom, S; Henderson, B; (2009) Pathogen burden and cortisol profiles over the day. EPIDEMIOL INFECT , 137 (12) 1816 - 1824. 10.1017/S0950268809002738. Green open access

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Abstract

Hypothalamic-pituitary-adrenocortical (HPA) regulation in adults is influenced by early psychosocial adversity, but the role of infectious disease history is poorly understood. We studied the association between cumulative pathogen burden and cortisol profile over the day in a sample of 317 healthy men and women aged 51-72 years. Cumulative pathogen burden was defined as positive serostatus for Chlamydia pneumoniae, cytomegalovirus (CMV) and herpes simplex virus 1 (HSV-1). Salivary cortisol was sampled repeatedly over the day. The cortisol slope was defined as the decrease across the day and evening. Age, gender, grade of employment, body mass index, smoking status, self-rated health, cardiovascular medication, depressed mood and time of waking were included as covariates. The pathogen burden averaged 1.76 (S.D. = 0.92). The cortisol slope was inversely associated with pathogen burden after controlling for covariates. When individual pathogens were studied, only CMV was associated with flatter cortisol rhythms in isolation. We conclude that pathogen burden is independently associated with flatter cortisol slopes over the day, and may contribute to disturbed neuroendocrine regulation.

Type: Article
Title: Pathogen burden and cortisol profiles over the day
Open access status: An open access version is available from UCL Discovery
DOI: 10.1017/S0950268809002738
Publisher version: http://dx.doi.org/10.1017/S0950268809002738
Language: English
Additional information: © 2009 Cambridge University Press
Keywords: Cortisol awakening response, Chlamydia pneumoniae, cytomegalovirus, herpes simplex virus 1, psychosocial adversity, SIMPLEX-VIRUS TYPE-1, EPSTEIN-BARR-VIRUS, ADVERSE CHILDHOOD EXPERIENCES, PITUITARY-ADRENAL AXIS, CORONARY-HEART-DISEASE, UNITED-STATES, CYTOMEGALOVIRUS-INFECTION, CARDIOVASCULAR-DISEASE, INDIVIDUAL-DIFFERENCES, HELICOBACTER-PYLORI
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Behavioural Science and Health
URI: https://discovery.ucl.ac.uk/id/eprint/111456
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