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The relationships between the HIV test interval, demographic factors and HIV disease progression

Sabin, CA; (2001) The relationships between the HIV test interval, demographic factors and HIV disease progression. EPIDEMIOL INFECT , 127 (1) 91 - 100. 10.1017/S0950268801005805. Green open access

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Abstract

Individuals developing an HIV seroconversion illness may experience rapid disease progression. Information on seroconversion illness is rarely collected in most cohort studies; thus the aim of this study was to assess the value of the HIV test interval (the time between last negative and first positive HIV tests) as a proxy for seroconversion illness. Among 8229 seroconverters, test intervals ranged from 0-5282 days, and varied by gender, risk group, age and calendar year of seroconversion. Those with intervals less than or equal to 31 days had an increased hazard of AIDS (RH 1.42, P = 0.07), which was reduced slightly after adjusting for baseline factors, calendar year of follow-up, treatment and the declining CD4 count, but there was no effect on survival. Thus, it appears that if information on acute seroconversion illness is not available, then analyses of progression to AIDS in seroconverter studies could use a short test interval as a proxy measure.

Type: Article
Title: The relationships between the HIV test interval, demographic factors and HIV disease progression
Open access status: An open access version is available from UCL Discovery
DOI: 10.1017/S0950268801005805
Publisher version: http://dx.doi.org/10.1017/S0950268801005805
Language: English
Additional information: © 2001 Cambridge University Press
Keywords: HUMAN-IMMUNODEFICIENCY-VIRUS, TYPE-1 INFECTION, DRUG-USERS, AIDS, SEROCONVERSION, ILLNESS, MANIFESTATIONS, SYMPTOMS, THERAPY, PLASMA
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/110328
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