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The rate of CD4 decline as a determinant of progression to AIDS independent of the most recent CD4 count

Lepri, AC; Sabin, CA; Phillips, AN; Lee, CA; Pezzotti, P; Rezza, G; (1998) The rate of CD4 decline as a determinant of progression to AIDS independent of the most recent CD4 count. EPIDEMIOL INFECT , 121 (2) 369 - 376. Green open access

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Abstract

The data of two cohort studies of HIV-infected individuals were used to examine whether the rate of CD4 decline is a determinant of HIV progression, independent of the most recent CD4 count. Time from seroconversion to clinical AIDS was the main outcome measure. Rates of CD4 decline were estimated using the ordinary least squares regression method. AIDS incidences were compared in individuals who had previously experienced either a steeper or a less steep rate of CD4 decline. Cox proportional hazards model including a time-dependent covariate for the rate of CD4 decline was performed. The rate of prior CD4 decline was significantly associated with the risk of developing AIDS independently from the most recent CD4 count, with a 2 % increase in hazard of AIDS (P < 0.01) for a difference of 10 cells/mm(3) in the estimated yearly drop in CD4 count. This finding gives scientific credit to the belief that individuals with a prior steeper CD4 decline consistently have a higher subsequent risk of developing AIDS than those with a less steep prior decline.

Type: Article
Title: The rate of CD4 decline as a determinant of progression to AIDS independent of the most recent CD4 count
Open access status: An open access version is available from UCL Discovery
Publisher version: http://journals.cambridge.org/action/displayAbstra...
Language: English
Additional information: © 1998 Cambridge University Press
Keywords: ACQUIRED-IMMUNODEFICIENCY-SYNDROME, HIV-1 RNA LEVELS, INCUBATION PERIOD, LYMPHOCYTE COUNTS, HEMOPHILIC COHORT, CUBIC MILLIMETER, VIRUS INFECTION, HOMOSEXUAL MEN, VIRAL LOAD, MARKERS
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/110209
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