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A Genome-Wide Association Study of Neuroticism in a Population-Based Sample

Calboli, FCF; Tozzi, F; Galwey, NW; Antoniades, A; Mooser, V; Preisig, M; Vollenweider, P; ... Balding, DJ; + view all (2010) A Genome-Wide Association Study of Neuroticism in a Population-Based Sample. PLOS ONE , 5 (7) , Article e11504. 10.1371/journal.pone.0011504. Green open access

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Abstract

Neuroticism is a moderately heritable personality trait considered to be a risk factor for developing major depression, anxiety disorders and dementia. We performed a genome-wide association study in 2,235 participants drawn from a population-based study of neuroticism, making this the largest association study for neuroticism to date. Neuroticism was measured by the Eysenck Personality Questionnaire. After Quality Control, we analysed 430,000 autosomal SNPs together with an additional 1.2 million SNPs imputed with high quality from the Hap Map CEU samples. We found a very small effect of population stratification, corrected using one principal component, and some cryptic kinship that required no correction. NKAIN2 showed suggestive evidence of association with neuroticism as a main effect (p<10(-6)) and GPC6 showed suggestive evidence for interaction with age (p approximate to 10(-7)). We found support for one previously-reported association (PDE4D), but failed to replicate other recent reports. These results suggest common SNP variation does not strongly influence neuroticism. Our study was powered to detect almost all SNPs explaining at least 2% of heritability, and so our results effectively exclude the existence of loci having a major effect on neuroticism.

Type: Article
Title: A Genome-Wide Association Study of Neuroticism in a Population-Based Sample
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0011504
Publisher version: http://dx.doi.org/10.1371/journal.pone.0011504
Language: English
Additional information: © 2010 Calboli et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The PsyCoLaus study was supported by grants from the Swiss National Science Foundation (#3200B0-105993, #3200B0-118308, 33CSCO-122661) and from GlaxoSmithKline (Psychiatry Center of Excellence for Drug Discovery and Genetics Division, Drug Discovery - Verona, R&D). F. Calboli was supported by a GSK grant to Imperial College London. GlaxoSmithKline had a role in study design, data analysis, decision to publish, and preparation of the manuscript: F. Tozzi, V. Mooser, D. Waterworth and N. W. Galwey are GlaxoSmithKline full-time employees. P. Muglia was a GlaxoSmithKline full-time employee at the time when this study was performed. M. Johnson was a GSK consultant at the time when the project was initiated.
Keywords: PERSONALITY-TRAIT NEUROTICISM, GENERALIZED ANXIETY DISORDER, CARDIOVASCULAR RISK-FACTORS, MAJOR DEPRESSION, LINKAGE ANALYSIS, ALZHEIMERS-DISEASE, 1ST ONSET, TWIN, HERITABILITY, GENES
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: https://discovery.ucl.ac.uk/id/eprint/106255
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