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TGF beta type II receptor signaling controls Schwann cell death and proliferation in developing nerves

D'Antonio, M; Droggiti, A; Feltri, ML; Roes, J; Wrabetz, L; Mirsky, R; Jessen, KR; (2006) TGF beta type II receptor signaling controls Schwann cell death and proliferation in developing nerves. J NEUROSCI , 26 (33) 8417 - 8427. 10.1523/JNEUROSCI.1578-06.2006. Green open access

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Abstract

During development, Schwann cell numbers are precisely adjusted to match the number of axons. It is essentially unknown which growth factors or receptors carry out this important control in vivo. Here, we tested whether the type II transforming growth factor (TGF)beta receptor has a role in this process. We generated a conditional knock-out mouse in which the type II TGF beta receptor is specifically ablated only in Schwann cells. Inactivation of the receptor, evident at least from embryonic day 18, resulted in suppressed Schwann cell death in normally developing and injured nerves. Notably, the mutants also showed a strong reduction in Schwann cell proliferation. Consequently, Schwann cell numbers in wild-type and mutant nerves remained similar. Lack of TGF beta signaling did not appear to affect other processes in which TGF beta had been implicated previously, including myelination and response of adult nerves to injury. This is the first in vivo evidence for a growth factor receptor involved in promoting Schwann cell division during development and the first genetic evidence for a receptor that controls normal developmental Schwann cell death.

Type: Article
Title: TGF beta type II receptor signaling controls Schwann cell death and proliferation in developing nerves
Open access status: An open access version is available from UCL Discovery
DOI: 10.1523/JNEUROSCI.1578-06.2006
Keywords: Schwann cell, proliferation, death, TGF beta, neuregulin, CRE recombinase, GROWTH-FACTOR-BETA, LINEAGE IN-VIVO, PERIPHERAL-NERVES, EXPRESSION, MYELINATION, VITRO, AXONS, MICE, DIFFERENTIATION, PHENOTYPE
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/10477
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