Horrocks, Edward AB;
Saleem, Aman B;
(2025)
Locomotion selectively enhances visual speed encoding in mouse medial higher visual areas.
iScience
, Article 114395. 10.1016/j.isci.2025.114395.
(In press).
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Abstract
Mammalian visual systems are comprised of multiple brain areas with distinct functional roles. Whilst functional specialisations have been proposed in the mouse based on visual feature encoding, the extent to which these specialisations are contingent on ongoing behaviour is unknown. To address this, we analysed neural encoding of visual motion stimuli by thousands of neurons recorded in six cortical and two thalamic visual areas while mice were stationary or locomoting. We found locomotion selectively enhanced visual speed encoding in medial higher visual cortical areas, indicating that these areas may be specialised for processing visual motion during locomotion. By contrast, encoding of drifting gratings direction was enhanced non-selectively across the mouse visual cortex during locomotion. Our results reveal how a complex interplay of sensory input and ongoing behaviour differentially shapes the efficacy of sensory processing in mouse higher visual areas, supporting context-dependent functional roles.
| Type: | Article |
|---|---|
| Title: | Locomotion selectively enhances visual speed encoding in mouse medial higher visual areas |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.isci.2025.114395 |
| Publisher version: | https://doi.org/10.1016/j.isci.2025.114395 |
| Language: | English |
| Additional information: | This is an open access article distributed under the terms of the Creative Commons CC-BY license, https://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Experimental Psychology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10219373 |
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