Terrett, Alice; Van Loo, Magalie; Sundararajan, Krishnaswamy; Brealey, David; Singer, Mervyn; Manson, Jessica; Raith, Eamon Patrick; (2025) Immune biomarkers and secondary hemophagocytic lymphohistiocytosis: a scoping review protocol. JBI Evidence Synthesis , 23 (1) pp. 158-164. 10.11124/JBIES-24-00133.

Text Singer_immune biomarkers secondary_hemophagocytic.8.pdf Access restricted to UCL open access staff until 3 January 2026. Download (263kB)

Abstract

Objective: The objective of this review is to identify immunological pathways and markers of severity of illness associated with clinical outcomes that may represent potential therapeutic targets in the management of secondary hemophagocytic lymphohistiocytosis. Introduction: A broad range of immunomodulatory therapies is used to manage hemophagocytic lymphohistiocytosis, however, the supporting evidence for these therapies is scarce. Identifying patients likely to experience more severe disease or die is currently extremely difficult, if not impossible. The identification of implicated cytokines in secondary disease can provide further support for the identification of high-risk patients and the development of targeted therapies. Inclusion criteria: Studies reporting immune biomarker and cytokine measurement in adult patients (age ≥18 years) with secondary hemophagocytic lymphohistiocytosis will be considered for inclusion. Methods: The proposed review will be conducted in line with the JBI methodology for scoping reviews. MEDLINE (Ovid) and Embase (Ovid) will be searched, without date limitations. Data will be extracted using a data extraction tool developed by the reviewers. Relevant sources will be retrieved, and their citation details imported into the JBI System for the Unified Management, Assessment and Review of Information.

Download activity - last month

Export as JSONXMLCSV

Download activity - last 12 months

Export as JSONXMLCSV

Downloads by country - last 12 months

Export as CSVJSONXML

Archive Staff Only

View Item