Newbold, K;
Armstrong, N;
Beasley, M;
Farnell, K;
Garcez, K;
Hassan, F;
Iqbal, S;
... Mallick, U; + view all
(2025)
Iodine or Not for Low-risk Differentiated Thyroid Cancer: How Should We Implement the Findings into UK Practice? An Expert Consensus Opinion.
Clinical Oncology
, 48
, Article 103954. 10.1016/j.clon.2025.103954.
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Hackshaw_Iodine or Not consensus paper 2025.pdf Access restricted to UCL open access staff until 15 October 2026. Download (535kB) |
Abstract
AIMS: To develop a national consensus on how to implement findings of recent practice changing Iodine or Not (IoN) trial. MATERIALS AND METHODS: A multidisciplinary group of UK clinicians specialising in the management of thyroid cancer was convened to discuss the impact of the IoN trial on the management of early stage, low risk differentiated thyroid cancer in the UK. Virtual meetings were held to discuss the trial data and to develop a position statement on how to implement the findings ahead of changes in national guidelines. RESULTS: A position statement providing recommendations for the managemnet of early stage, low risk differentiated thyroid cancer based on the group consensus opinion and interpretation of the IoN trial data was defined. CONCLUSION: The Iodine or Not (IoN) trial was a UK multicentre prospective randomised controlled trial that investigated the role of radioiodine ablation in early stage, low-risk differentiated thyroid cancer. The findings showed non-inferiority of omitting radioiodine in terms of recurrence-free survival. This provides level 1 evidence to support sparing many patients with low-risk thyroid cancer treatment with radioiodine and the possible associated treatment-related adverse events. Ahead of changes in national and international guidelines this multidisciplinary group of specialists involved in the management of thyroid cancer proposes a position statement on how to implement these findings into UK practice.
| Type: | Article |
|---|---|
| Title: | Iodine or Not for Low-risk Differentiated Thyroid Cancer: How Should We Implement the Findings into UK Practice? An Expert Consensus Opinion |
| Location: | England |
| DOI: | 10.1016/j.clon.2025.103954 |
| Publisher version: | https://doi.org/10.1016/j.clon.2025.103954 |
| Language: | English |
| Additional information: | © 2025 The Royal College of Radiologists. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies. |
| Keywords: | Cancer, consensus, IoN, radioiodine, thyroid |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > CRUK Cancer Trials Centre |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10218705 |
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