Rehwald, Rafael;
Sokolska, Magdalena;
Sudre, Carole H;
Smith, Lorna;
Tillin, Therese;
Atkinson, David;
Chaturvedi, Nishi;
... Jäger, Hans Rolf; + view all
(2025)
Cerebral blood flow in a tri-ethnic population: insights from pCASL perfusion MRI.
European Radiology
10.1007/s00330-025-12160-5.
(In press).
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Abstract
Objectives: Arterial transit artefacts (ATAs) on pseudo-continuous arterial spin labelling (pCASL) MRI represent visual markers of delayed arterial transit. This study aimed to investigate their prevalence and distribution and to evaluate the effects of sex, ethnicity, intracranial arterial anatomy, and cardiovascular parameters in a subgroup of the UK tri-ethnic population-based Southall and Brent REvisited (SABRE) study. // Materials and methods: We analysed 360 participants—120 each of White European, South Asian, and African Caribbean origin—from the prospective SABRE cohort who underwent 3.0-T brain MRI and clinical assessment between 2014 and 2018. ATAs were visually rated across 40 predefined brain regions on pCASL perfusion images and summarised as percentage ATA scores. Intracranial arterial anatomy was classified on time-of-flight MR angiography, and cardiovascular parameters were obtained from clinical assessment. ATAs were compared by sex and ethnicity, and associations with demographic, anatomical, and cardiovascular factors were analysed using multivariable regression. // Results: Of 360 participants, 284 (78.89%; mean age 70.12 ± 6.58 years; range 49–89; 139 women) had usable pCASL data. ATA prevalence varied across vascular territories and between women and men. African Caribbean participants showed a higher frequency of ATAs in the posterior circulation, whereas in most anterior territories they had fewer ATAs than White Europeans or South Asians. // Conclusion: Visual rating of ATAs revealed sex- and ethnicity-specific differences in ATA distribution, reflecting variations in arterial transit time influenced by intracranial vascular anatomy and cardiovascular parameters. These findings highlight the potential of ATAs as imaging markers for personalised cerebrovascular assessment and risk stratification.
| Type: | Article |
|---|---|
| Title: | Cerebral blood flow in a tri-ethnic population: insights from pCASL perfusion MRI |
| Location: | Germany |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s00330-025-12160-5 |
| Publisher version: | https://doi.org/10.1007/s00330-025-12160-5 |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| Keywords: | Spin labels; Artefacts; Cerebrovascular circulation; Brain; Ethnicity |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10218695 |
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