Ahmad, Reem;
Coos, Richard;
Patallo, Ileana Silvestre;
Baker, Colin;
Brunet, Christian;
Cini, Nilsu;
Gosling, Andrew;
... Hawkins, Maria; + view all
(2025)
Proof of concept for the usability of the IRRAMICE for proton preclinical radiobiological research by a traceable dosimetry evaluation.
Scientific Reports
, 15
(1)
, Article 40762. 10.1038/s41598-025-24546-y.
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Abstract
Radiobiology relies on animal studies to demonstrate efficacy and safety of treatments. For proton-based studies in clinical settings, bespoke solutions, enabling animal irradiations without compromising health and safety regulations, need to be developed to facilitate the research. This study aims to demonstrate the usability of the IRRAMICE, a novel system with bespoke collimators to effectively treat small targets, within proton clinical facilities. Following a clinical workflow of planning CT, treatment plan design and delivery, a dosimetric evaluation of the IRRAMICE was conducted. Traceable absorbed dose was determined by measurements with (i) ion chamber, (ii) alanine pellets within a mouse phantom and a bespoke holder in the IRRAMICE, and (iii) Gafchromic film in the holder for a relative evaluation of the collimation system. Dose determined with alanine pellets in the mouse phantom were within 2% of the planned dose. The 2%/2 mm local gamma analysis of the dose distribution of the collimated beam spot determined by the film and the treatment planning system showed an average 98.3% passing rate. Through measurements in mouse phantoms, IRRAMICE demonstrated to be a suitable device for enabling the setup and delivery of treatment plans in a reliable and reproducible manner, to facilitate in vivo preclinical experiments.
| Type: | Article |
|---|---|
| Title: | Proof of concept for the usability of the IRRAMICE for proton preclinical radiobiological research by a traceable dosimetry evaluation |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41598-025-24546-y |
| Publisher version: | https://doi.org/10.1038/s41598-025-24546-y |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| Keywords: | Dosimetry, IRRAMICE, Preclinical, Proton therapy, Animals, Mice, Phantoms, Imaging, Radiometry, Proton Therapy, Radiobiology, Radiotherapy Dosage, Radiotherapy Planning, Computer-Assisted, Proof of Concept Study |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10217614 |
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