Miedema, Martijn;
Yerworth, Rebecca;
Waldmann, Andreas;
Frerichs, Inéz;
Bayford, Richard;
Van Kaam, Anton;
(2025)
Changes in lung volume and ventilation during Apnoea of Prematurity using EIT.
Pediatric Pulmonology
, 60
(11)
, Article e71369. 10.1002/ppul.71369.
(In press).
Preview |
Text
Yerworth_Pediatric Pulmonology - 2025 - Miedema - Changes in Lung Volume and Ventilation During Apnoea of Prematurity Using EIT.pdf Download (324kB) | Preview |
Abstract
BACKGROUND: Central Apnoea of prematurity (AoP) is a common complication in preterm infants. AoP impact oxygenation but it is unclear what its effect is on lung volume and ventilation distribution. Electrical Impedance Tomography is a technique able to continuously and bedside monitor lung volume changes in preterm infants. METHODS: In a subset of preterm infants of the CRADL project (Continuous Regional Analysis device for neonate Lung) we extracted, using a self-developed automatic detection algorithm and followed by a hand check central AoP, EIT tracings. These EIT tracings were analysed pre-, during and post apnoea for changes in relative end expiratory lung impedance (EELI), tidal volume, breathing rate, minute volume and ventilation distribution. RESULTS: In 15 preterm infants, 203 apnoeas were identified and included into this study. During apnoeas a significant drop (p < 0.05) in relative EELI was seen but this restored to pre-apnoea levels, mediated by an increased median tidal volume (0.43 AU [0.34-0.57] to 0.57 AU [0.47-0.70], p < 0.05). Ventilation distribution on a regional level (right-left, anterior-posterior or centre of ventilation) showed no changes pre- and post- apnoea. CONCLUSION: Central AoP results in a significant decrease in EELI but this restores to pre-apnoea levels by compensatory increased tidal volume. No changes in ventilation distribution were detected after an apnoea.
| Type: | Article |
|---|---|
| Title: | Changes in lung volume and ventilation during Apnoea of Prematurity using EIT |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/ppul.71369 |
| Publisher version: | https://doi.org/10.1002/ppul.71369 |
| Language: | English |
| Additional information: | © 2025 The Author(s). Pediatric Pulmonology published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| Keywords: | apnoea of Prematurity, electrical impedance tomography, nCPAP, newborn, preterm infant, Humans, Infant, Newborn, Electric Impedance, Tidal Volume, Infant, Premature, Tomography, Female, Male, Lung, Lung Volume Measurements, Sleep Apnea, Central |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10217420 |
Archive Staff Only
 |
View Item |
