Wang, Kaihong;
Armour, Chlöe H;
Gibbs, Richard GJ;
Xu, Xiao Yun;
(2024)
A numerical study of the effect of thrombus breakdown on predicted thrombus formation and growth.
Biomechanics and Modeling in Mechanobiology
, 23
(1)
pp. 61-71.
10.1007/s10237-023-01757-8.
Preview |
Text
s10237-023-01757-8.pdf - Published Version Download (1MB) | Preview |
Abstract
Thrombosis is a complex biological process which involves many biochemical reactions and is influenced by blood flow. Various computational models have been developed to simulate natural thrombosis in diseases such as aortic dissection (AD), and device-induced thrombosis in blood-contacting biomedical devices. While most hemodynamics-based models consider the role of low shear stress in the initiation and growth of thrombus, they often ignore the effect of thrombus breakdown induced by elevated shear stress. In this study, a new shear stress-induced thrombus breakdown function is proposed and implemented in our previously published thrombosis model. The performance of the refined model is assessed by quantitative comparison with experimental data on thrombus formation in a backward-facing step geometry, and qualitative comparison with in vivo data obtained from an AD patient. Our results show that incorporating thrombus breakdown improves accuracy in predicted thrombus volume and captures the same pattern of thrombus evolution as measured experimentally and in vivo. In the backward-facing step geometry, thrombus breakdown impedes growth over the step and downstream, allowing a stable thrombus to be reached more quickly. Moreover, the predicted thrombus volume, height and length are in better agreement with the experimental measurements compared to the original model which does not consider thrombus breakdown. In the patient-specific AD, the refined model outperforms the original model in predicting the extent and location of thrombosis. In conclusion, the effect of thrombus breakdown is not negligible and should be included in computational models of thrombosis.
| Type: | Article |
|---|---|
| Title: | A numerical study of the effect of thrombus breakdown on predicted thrombus formation and growth |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s10237-023-01757-8 |
| Publisher version: | https://doi.org/10.1007/s10237-023-01757-8 |
| Language: | English |
| Additional information: | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| Keywords: | Thrombosis modeling, Computational fluid dynamics, Hemodynamics, Backward-facing step, Thrombus breakdown, Shear stress |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10216260 |
Archive Staff Only
 |
View Item |
