Wolfson, Paul;
(2025)
Expanding technological horizons for treatment and staging early oesophageal cancer.
Doctoral thesis (Ph.D), UCL (University College London).
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Abstract
Background: Barrett’s dysplasia confers significantly greater risk of developing oesophageal adenocarcinoma (OAC) which has poor outcomes. Radiofrequency ablation (RFA) has become established therapy for Barrett’s dysplasia. Long-term data is lacking. Staging is the most accurate reflection of cancer prognosis. Accuracy of this staging is conflicting. I aim to establish if: I. outcomes from RFA are durable and reduce the risk of developing OAC II. T2N0 oesophageal cancer staging is accurate III. x-ray phase imaging (XPCI) can stage and grade oesophageal tissues / Methods: Analysis of the UK RFA registry was conducted to calculate rates of invasive cancer, clearance rates of dysplasia (CR-D) and intestinal metaplasia (CR-IM). Accuracy of oesophageal cancer staging was established using a systematic review. To grade and stage oesophageal tissues XPCI techniques were used. / Results: Ten-years after RFA therapy, cancer rate was 4.1%. CR-D and CR-IM after 2 years of therapy were 88% and 62.6%. Persistance rates were 5.9% from CR-D and 18.7% from CR-IM at 8 years, most recurrences occurred within 2 years.
| Type: | Thesis (Doctoral) |
|---|---|
| Qualification: | Ph.D |
| Title: | Expanding technological horizons for treatment and staging early oesophageal cancer |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| Additional information: | Copyright © The Author 2025. Original content in this thesis is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) Licence (https://creativecommons.org/licenses/by-nc/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request. |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10216099 |
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