Latiyan, Sachin;
Gugulothu, Sriram Bharath;
Agarwal, Piyush;
Waidi, Yusuf Olatunji;
Homer-Vanniasinkam, Shervanthi;
Visweswariah, Sandhya S;
Chatterjee, Kaushik;
(2025)
4D bioprinting of silkworm sericin-based hydrogels fabricated by digital light projection of visible light.
Materials Today Chemistry
, 49
, Article 103061. 10.1016/j.mtchem.2025.103061.
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Abstract
Three-dimensional (3D) printed natural polymer-based structures have garnered increased demand in textiles, robotics, biomedical, and tissue engineering. Integrating time-dependent dynamic shape deformation in such four-dimensional (4D) printed structures could open new avenues for advancing healthcare. Sericin is a globular protein that has been discarded as a textile byproduct despite its broad utility in producing materials and cytocompatibility. Herein, we formulated a photo-cross-linkable bioink using sericin and poly(ethylene) glycol dimethacrylate (PEGDM) for printing shape-morphing 4D scaffolds. PEGDM augmented the printability and mechanical stability of the sericin-based constructs prepared by digital light processing (DLP) based 3D bioprinters. Printing parameters were tailored to induce crosslinking anisotropy in the constructs for differential swelling in response to hydration. The physical properties of the 3D-printed constructs were tuned by systematically varying prepolymer concentrations and printing parameters. The cytocompatibility of cell-laden 4D-bioprinted scaffolds was demonstrated by confirming the viability and proliferation of NIH/3T3 murine fibroblasts. This study establishes 4D bioprinting of sericin-based hydrogels, which can be explored further for actuators, soft robotics, tissue engineering, and other biomedical applications.
| Type: | Article |
|---|---|
| Title: | 4D bioprinting of silkworm sericin-based hydrogels fabricated by digital light projection of visible light |
| DOI: | 10.1016/j.mtchem.2025.103061 |
| Publisher version: | https://doi.org/10.1016/j.mtchem.2025.103061 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Biomaterials; Additive manufacturing; Biopolymers; Tissue engineering; Hydrogels |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10216045 |
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