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DIGS: Dynamic CBCT Reconstruction Using Deformation-Informed 4D Gaussian Splatting and a Low-Rank Free-Form Deformation Model

Huang, Y; Singh, I; Joyce, T; Thielemans, K; McClelland, JR; (2025) DIGS: Dynamic CBCT Reconstruction Using Deformation-Informed 4D Gaussian Splatting and a Low-Rank Free-Form Deformation Model. In: Medical Image Computing and Computer Assisted Intervention – MICCAI 2025. (pp. pp. 131-141). Springer Nature

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Abstract

3D Cone-Beam CT (CBCT) is widely used in radiotherapy but suffers from motion artifacts due to breathing. A common clinical approach mitigates this by sorting projections into respiratory phases and reconstructing images per phase, but this does not account for breathing variability. Dynamic CBCT instead reconstructs images at each projection, capturing continuous motion without phase sorting. Recent advancements in 4D Gaussian Splatting (4DGS) offer powerful tools for modeling dynamic scenes, yet their application to dynamic CBCT remains underexplored. Existing 4DGS methods, such as HexPlane, use implicit motion representations, which are computationally expensive. While explicit low-rank motion models have been proposed, they lack spatial regularization, leading to inconsistencies in Gaussian motion. To address these limitations, we introduce a free-form deformation (FFD)-based spatial basis function and a deformation-informed framework that enforces consistency by coupling the temporal evolution of Gaussian’s mean position, scale, and rotation under a unified deformation field. We evaluate our approach on six CBCT datasets, demonstrating superior image quality with a 6× speedup over HexPlane. These results highlight the potential of deformation-informed 4DGS for efficient, motion-compensated CBCT reconstruction. The code is available at https://github.com/Yuliang-Huang/DIGS.

Type: Proceedings paper
Title: DIGS: Dynamic CBCT Reconstruction Using Deformation-Informed 4D Gaussian Splatting and a Low-Rank Free-Form Deformation Model
Event: 28th International Conference – MICCAI 2025
ISBN-13: 978-3-032-04964-3
DOI: 10.1007/978-3-032-04965-0_13
Publisher version: https://doi.org/10.1007/978-3-032-04965-0_13
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: Dynamic CBCT, 4D Gaussian Splatting, Deformation Informed
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10215987
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