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Effects of preconception nutrition interventions on pregnancy and birth outcomes in South Asia: a systematic review

Saville, Naomi M; Dulal, Sophiya; Miller, Faith; Schoenaker, Danielle; Chowdhury, Ranadip; Hazra, Avishek; Hirst, Jane; ... Sethi, Vani; + view all (2025) Effects of preconception nutrition interventions on pregnancy and birth outcomes in South Asia: a systematic review. The Lancet Regional Health - Southeast Asia , 36 , Article 100580. 10.1016/j.lansea.2025.100580. Green open access

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Abstract

Undernutrition amongst reproductive age women, low birth weight, small for gestational age and preterm birth present significant health burdens in South Asia which interventions in pregnancy alone have not resolved. Effectiveness of preconception nutrition interventions is not well-documented. This systematic review summarises evidence on the effect of preconception nutrition interventions on pregnancy and birth outcomes in South Asia. We found highly heterogeneous evidence across four micronutrient supplementation, two food supplementation, and three complex interventions trials. Preconception micronutrient supplementation alone did not affect birth size, but food supplementation was effective with and without multiple micronutrients, especially when initiated at least 90 days before conception. Combined health, nutrition, psychosocial care, and WaSH interventions addressing determinants at multiple levels were most effective. However intensive delivery by project employees poses problems for scale-up. More robust South Asian preconception intervention trials to identify scalable interventions that are effective in real-world delivery settings are needed. // Funding: UNICEF Regional Office for South Asia contract number 43384734.

Type: Article
Title: Effects of preconception nutrition interventions on pregnancy and birth outcomes in South Asia: a systematic review
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.lansea.2025.100580
Publisher version: https://doi.org/10.1016/j.lansea.2025.100580
Language: English
Additional information: Copyright © 2025 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Preconception nutrition; South asia; Systematic review; Birth outcomes; Pregnancy outcomes; Micronutrient supplementation; Food supplementation; Complex intervention
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Reproductive Health
URI: https://discovery.ucl.ac.uk/id/eprint/10215853
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