Duca, Stefana;
Parvar, Sara Jamshidi;
Kumeta, Luke;
Bradshaw, Tracey D;
Chan, Weng C;
de Cogan, Felicity;
Dziemidowicz, Karolina;
... Lewis, Andrew L; + view all
(2025)
Drug delivery strategies for paediatric diffuse midline gliomas.
Advanced Drug Delivery Reviews
, Article 115695. 10.1016/j.addr.2025.115695.
(In press).
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Abstract
Diffuse midline gliomas (DMGs) are a highly aggressive and inoperable type of paediatric brain tumours, with a median survival of less than one year. Therapeutic progress has been hindered by the tumour's anatomical location, its extensive molecular heterogeneity, and the restrictive nature of the blood brain barrier (BBB) in drug delivery. This article explores the current therapeutic landscape of DMG and evaluates emerging drug delivery strategies, including oral, intravenous and intrathecal administration, convection-enhanced delivery (CED), and intranasal approaches, designed to improve drug access to the brain. Advancements in these methods, combined with targeted therapies tailored to the tumour's unique molecular features, represent a critical pathway towards improving clinical outcomes for DMG patients.
| Type: | Article |
|---|---|
| Title: | Drug delivery strategies for paediatric diffuse midline gliomas |
| Location: | Netherlands |
| DOI: | 10.1016/j.addr.2025.115695 |
| Publisher version: | https://doi.org/10.1016/j.addr.2025.115695 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | CED, DMG, DIPG, Drug delivery, Intranasal, Intrathecal, Paediatric gliomas |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10214757 |
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