Young, William J;
Lambiase, Pier D;
(2025)
Challenges in the treatment of patients with Brugada syndrome: The current role of ablation.
Kardiol Pol
10.33963/v.phj.106867.
(In press).
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Abstract
Brugada syndrome is an inherited ion channelopathy associated with an increased risk for ventricular arrhythmia and sudden death. Current management strategies to reduce arrhythmic risk are limited, with few pharmacological options that may be ineffective or cause side-effects leading to suboptimal dosing or cessation of treatment. There is substantial interest therefore in determining the long-term efficacy and safety profile of catheter ablation, to targeting triggers and electrophysiological substrates for ventricular arrhythmia. With the recent publication of small, randomized trials including the BRAVE study, the level of evidence is improving. However, the balance of risk verses benefit across the arrhythmic risk spectrum remains unclear and procedural technical challenges remain, particularly given most patients will require an epicardial approach for catheter ablation. This review outlines the current evidence in the published literature and highlights gaps in knowledge that should be prioritised in future studies.
| Type: | Article |
|---|---|
| Title: | Challenges in the treatment of patients with Brugada syndrome: The current role of ablation |
| Location: | Poland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.33963/v.phj.106867 |
| Publisher version: | https://doi.org/10.33963/v.phj.106867 |
| Language: | English |
| Additional information: | © The Author(s), 2025. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CC-BY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Keywords: | Brugada syndrome, ablation, ventricular tachycardia |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Clinical Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10214487 |
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